實驗室研究方向：

t cells play essential roles in immune response. we are studying t cells with two directions:

1. functional genomics in primary t cells

we are applying genome-wide crispr/cas9 screen in primary t cell in vivo to answer fundamental questions in t cell biology, including development, activation, proliferation and differentiation, as well as t cell fitness (e.g. exhaustion) in tumor microenvironment. identified novel genes and regulatory circuits have been used to design novel therapies for diseases.

2. mechanisms of metabolic regulation of t cells

metabolic reprogramming is a hallmark of t cell activation, but how metabolic pathways regulate t cell function remains poorly understood. we are using mouse models with gain- and loss-of-function of key metabolic enzymes to decipher metabolic regulation t cell, and try to target metabolism to treat immune-related diseases.

近期代表性成果如下，

1.min peng, na yin, ming o. li. szt2 dictates gator control of mtorc1 signaling.nature. 2017 mar 16;543(7645):433-437.

2.min peng*, na yin*, sagar chhangawala, ke xu, christina s. leslie, ming o. li. aerobic glycolysis promotes t helper 1 cell differentiation through an epigenetic mechanism.science, 2016 oct 28; 354(6311): 481-484.*equal contribution.

preview inscience, 2016 oct 28; 354(6311): 419-420.“warburg meets epigenetics”.

preview indev cell, 2016 november 7;39: 286-287.“metabolic control of cellular differentiation”.

preview incell metab, 2016 november 8; 24: 651-652.“metabolic signaling drives ifn-g”.

3.min peng, na yin, ming o. li. sestrins function as guanine nucleotide dissociation inhibitors for rag gtpases to control mtorc1 signaling.cell. 2014 sep 25; 159(1): 122-33.

highlighted innat rev mol cell biol, 2014; 15: 701,“a rag dissociation inhibitor”.

博士后招聘1-2名：

應聘條件：具有免疫學、分子和細胞生物學相關專業博士學位，獲得博士學位1年以內；近期以第一作者身份在國際知名學術期刊發表研究論文，符合清華大學博士后入站標準，年齡小于35周歲；熱愛科研工作，責任心強，具備團隊合作精神；具備較好的英語溝通、閱讀和寫作能力。

崗位待遇：在清華大學校定博士后工資待遇基礎上，根據工作經驗和能力可以享受具有國際競爭力的年薪式津貼。符合條件者，支持申請國家“博新計劃”、清華“水木學者”、以及生命科學聯合中心博士后獎學金支持計劃。

申請方式：將簡歷（包括學歷和論文發表情況）、研究自述（研究興趣、成果以及未來職業規劃）、及2-3名推薦人的聯系方式發至：；主題標明“姓名+應聘博士后+高校人才網“。

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